Abstract
This review covers the 1994-2014 literature data published for anti-CNS tumour natural products isolated from marine sponges. The focus was on highly potent antitumourics. It describes only eight promising bioactives (screened on even less number of the respective cell lines) suggesting that brain tumours actually represent quite a hot topic for the natural product research community worldwide.
Keywords:
Porifera; brain tumours; natural products; new leads.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Aquatic Organisms
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Biological Products / chemistry
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Biological Products / pharmacology
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Brain Neoplasms / drug therapy
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Central Nervous System Neoplasms / drug therapy*
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Dioxanes / chemistry
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Dioxanes / pharmacology
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Diterpenes / chemistry
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Diterpenes / pharmacology
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Humans
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Porifera / chemistry*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology
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Terpenes / chemistry
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Terpenes / pharmacology
Substances
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Antineoplastic Agents
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Biological Products
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Dioxanes
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Diterpenes
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Heterocyclic Compounds, 4 or More Rings
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Pyrimidines
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Terpenes
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axistatin 1
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dibromophakellin
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plakortide M
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sesterstatin 5