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J Vet Sci. 2017 Dec 31;18(4):431-437. doi: 10.4142/jvs.2017.18.4.431.

Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis.

Zhang L1,2,3, Zhao L1,2, Liu Y1,2, Liu J2, Li X1,2.

Author information

1
College of Animal Science and Technology, Tarim University, Alar 843300, China.
2
Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China.
3
College of Animal Science & Technology, Shihezi University, Shihezi 832000, China.

Abstract

A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations. Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet detection at 285 nm. PK parameters were calculated by using WinNonlin software. After TIL administration, the main PK parameters of TIL in healthy and H. parasuis-infected pigs were as follows: Area under the concentration-time curve, maximal drug concentration, half-life of the absorption phase, half-life of the distribution phase, and half-life of the elimination phase were 34.86 ± 9.69 vs. 28.73 ± 6.18 μgㆍh/mL, 1.77 ± 0.33 vs. 1.67 ± 0.28 μg/mL, 2.27 ± 0.45 vs. 2.24 ± 0.44 h, 5.35 ± 1.40 vs. 4.61 ± 0.35 h, and 43.53 ± 8.17 vs. 42.05 ± 9.36 h, respectively. These results of this exploratory study suggest that there were no significant differences between the PK profiles of TIL in the healthy and H. parasuis-infected pigs.

KEYWORDS:

Haemophilus parasuis; high pressure liquid chromatography; infected pigs; pharmacokinetics; tilmicosin

PMID:
28385011
PMCID:
PMC5746435
DOI:
10.4142/jvs.2017.18.4.431
[Indexed for MEDLINE]
Free PMC Article

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