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J Biomed Opt. 2017 Apr 1;22(4):45003. doi: 10.1117/1.JBO.22.4.045003.

Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy.

Author information

1
University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
2
University of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
3
University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United StatescLinköping University, Department of Biomedical Engineering, Linköping, Sweden.
4
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.

Abstract

Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are model-based near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, ? a , and reduced scattering, ? s ? ) and blood flow (blood flow index, BFI), respectively. DOSI-derived ? a values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin ( HbO 2 , HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 ?? mm ? 1 (37%) in ? s ? and 0.003 ?? mm ? 1 (33%) in ? a lead to ? 53 % and 9% errors in BFI, respectively. DOSI/DCS imaging of a solid tissue-simulating flow phantom and.

PMID:
28384703
PMCID:
PMC5381696
DOI:
10.1117/1.JBO.22.4.045003
[Indexed for MEDLINE]
Free PMC Article

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