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Curr Protoc Hum Genet. 2017 Apr 6;93:10.14.1-10.14.29. doi: 10.1002/cphg.37.

Molecular Analysis of Genetic Markers for Non-Hodgkin Lymphomas.

Author information

1
Brigham and Women's Hospital, Boston, Massachusetts.
2
Yale New Haven Hospital, New Haven, Connecticut.

Abstract

Molecular analysis complements the clinical and histopathologic tools used to diagnose and subclassify hematologic malignancies. The presence of clonal antigen-receptor gene rearrangements can help to confirm the diagnosis of a B or T cell lymphoma and can serve as a fingerprint of that neoplasm to be used in identifying concurrent disease at disparate sites or recurrence at future time points. Certain lymphoid malignancies harbor a characteristic chromosomal translocation, a finding that may have significant implications for an individual's prognosis or response to therapy. The polymerase chain reaction (PCR) is typically used to detect antigen-receptor gene rearrangements as well as specific translocations that can be supplemented by fluorescence in situ hybridization (FISH) and karyotype analysis.

KEYWORDS:

antigen receptor gene rearrangements; lymphoma; translocations

PMID:
28384399
DOI:
10.1002/cphg.37
[Indexed for MEDLINE]

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