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Medicine (Baltimore). 2017 Apr;96(14):e6657. doi: 10.1097/MD.0000000000006657.

Risk for Irritable Bowel Syndrome in Fibromyalgia Patients: A National Database Study.

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aMolecular and Genomic Epidemiology Center, China Medical University Hospital, China Medical University, Taichung bDivision of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua cDivision of Chinese Trauma, China Medical University Hospital dManagement Office for Health Data, China Medical University Hospital eCollege of Medicine, China Medical University, Taichung fDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi gChang Gung University, Taoyuan hKau-Tang Traditional Medical Hospital iDepartment of Nuclear Medicine and PET Center, China Medical University Hospital jGraduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.


Various studies have shown that irritable bowel syndrome (IBS) is highly associated with other pathologies, including fibromyalgia (FM). The objective of this study was to analyze the differences among risk factors associated with IBS following FM in a nationwide prospective cohort study.We propose that a relationship exists between FM and IBS. This article presents evidence obtained from a cohort study in which we used data from the Taiwan National Health Insurance Research Database to clarify the relationship between FM and IBS. The follow-up period ran from the start of FM diagnosis to the date of the IBS event, censoring, or December 31, 2011. We analyzed the risk of IBS using Cox proportional hazard regression models, including sex, age, and comorbidities.During the follow-up period, from 2000 to 2011, the overall incidence of IBS was higher in FM patients than in non-FM patients (7.47 vs 4.42 per 1000 person-years), with a crude hazard ratio = 1.69 (95% confidence interval [CI] 1.59-1.79). After adjustment for age, sex, and comorbidities, FM was associated with a 1.54-fold increased risk for IBS.Mutually risk factors may influence the relationship between FM and IBS. We recommend that physiologists conduct annual examinations of FM patients to reduce the incidence of IBS progression.

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