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Exp Gerontol. 1988;23(1):19-24.

Age-related changes in rat liver plasma membrane sphingomyelinase activity.

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  • 1Central Laboratory of Biophysics, Bulgarian Academy of Sciences, Sofia.


The age-induced changes of some phospholipid fractions, membrane fluidity and neutral membrane-bound sphingomyelinase (EC activity in rat liver plasma membranes have been investigated. Alterations in the percentage participation of phosphatidylcholine and sphingomyelin with aging have been established. Regression analysis indicated a positive linear correlation (r = 0.927) between the membrane-bound neutral sphingomyelinase activity and the phosphatidylcholine percent in the total plasma membrane phospholipids, as well as a negative linear correlation (r = -0.937) between the enzyme activity and the sphingomyelin/phosphatidylcholine ratio.

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