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FEBS J. 2017 Apr;284(8):1178-1181. doi: 10.1111/febs.14054. Epub 2017 Apr 5.

AIDing-targeted protein degradation in Drosophila.

Author information

1
Muscle Dynamics Group, Max Planck Institute of Biochemistry, Martinsried, Germany.
2
Developmental Biology Institute of Marseille (IBDM), CNRS, UMR 7288, Aix-Marseille Université, France.

Abstract

Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).

PMID:
28382696
DOI:
10.1111/febs.14054
[Indexed for MEDLINE]
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