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Endocr Connect. 2017 May;6(4):R52-R58. doi: 10.1530/EC-17-0021. Epub 2017 Apr 5.

Gut-thyroid axis and celiac disease.

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B. Rappaport School of MedicineTechnion-Israel Institute of Technology, Haifa, Israel
AESKU.KIPP InstituteWendelsheim, Germany.


Autoimmune thyroiditis has an increased prevalence in patients with celiac disease and vice versa. The objective of the current review is to highlight the epidemiological, clinical, serological, pathological, pathophysiological, hormonal, genetic and immunological factors shared between the two entities. They might represent the two ends of the gut-thyroid axis where the cross-talks' pathways are still unravelled. New observations are reviewed, highlighting some gut-thyroid interrelated pathways that potentially might lead to new therapeutic strategies.


Hashimoto’s thyroiditis; autoimmunity; celiac disease; intestine; thyroid

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