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Ann Neurol. 1988 Apr;23(4):385-9.

Fatal adenovirus meningoencephalitis in a bone marrow transplant patient.

Author information

1
Department of Pathology, University of Kentucky, Lexington 40536.

Abstract

We describe a bone marrow transplant patient with fatal subacute adenovirus meningoencephalitis, the first such patient reported. Neuropathological examination revealed unique, bilaterally symmetrical degeneration in the inferomedial temporal cortex, amygdaloid nuclei, hippocampi, hypothalamus, and some brainstem nuclei. Viral intranuclear inclusions were noted in these areas by light microscopy and confirmed by electron microscopy. Identification was authenticated by viral culture and the isolation of adenovirus from cerebral cortical tissues, and further confirmed by immunofluorescence and serological methods.

PMID:
2837977
DOI:
10.1002/ana.410230412
[Indexed for MEDLINE]

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