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High Blood Press Cardiovasc Prev. 2017 Jun;24(2):115-126. doi: 10.1007/s40292-017-0196-1. Epub 2017 Apr 4.

Cardiac Natriuretic Peptides, Hypertension and Cardiovascular Risk.

Author information

1
Internal Medicine and Geriatrics, Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Ancona, Italy. r.sarzani@univpm.it.
2
Italian National Research Centre on Aging, Hospital "U. Sestilli", IRCCS-INRCA, via della Montagnola n. 81, 60127, Ancona, Italy. r.sarzani@univpm.it.
3
Internal Medicine and Geriatrics, Department of Clinical and Molecular Sciences, University "Politecnica delle Marche", Ancona, Italy.
4
Italian National Research Centre on Aging, Hospital "U. Sestilli", IRCCS-INRCA, via della Montagnola n. 81, 60127, Ancona, Italy.

Abstract

Prevalence of cardiovascular (CV) disease is increasing worldwide. One of the most important risk factors for CV disease is hypertension that is very often related to obesity and metabolic syndrome. The search for key mechanisms, linking high blood pressure (BP), glucose and lipid dysmetabolism together with higher CV risk and mortality, is attracting increasing attention. Cardiac natriuretic peptides (NPs), including ANP and BNP, may play a crucial role in maintaining CV homeostasis and cardiac health, given their impact not only on BP regulation, but also on glucose and lipid metabolism. The summa of all metabolic activities of cardiac NPs, together with their CV and sodium balance effects, may be very important in decreasing the overall CV risk. Therefore, in the next future, cardiac NPs system, with its two receptors and a neutralizing enzyme, might represent one of the main targets to treat these multiple related conditions and to reduce hypertension and metabolic-related CV risk.

KEYWORDS:

Cardiac natriuretic peptides; Cardiovascular risk; Hypertension; Metabolism; Obesity

PMID:
28378069
PMCID:
PMC5440492
DOI:
10.1007/s40292-017-0196-1
[Indexed for MEDLINE]
Free PMC Article

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