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Ann Biol Clin (Paris). 2017 Apr 1;75(2):193-203. doi: 10.1684/abc.2017.1227.

Hypervitaminemia B12 and malignant diseases: report of a cross-sectional study in an acute geriatric unit.

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Département de médecine interne-gériatrie-thérapeutique, CHU Rouen, Hôpital Saint-Julien, Le Petit-Quevilly, France.
Unité d'aide méthodologique, Pôle recherche et innovations, CHU Reims, Reims, France.
Département de médicine interne, diabètes et désordres métaboliques, CHRU Strasbourg, Strasbourg, France.


Hypervitaminemia B12 has been associated or linked with a range of conditions, the majority of which are serious. Between March 26th, 2014 and June 30th, 2014, all patients aged ≥65 years, hospitalized in an acute geriatric unit in the university hospital center of Reims (France) were included in an observational study. 190 patients were included. 48 patients presented a hypervitaminemia B12 (25.3%). The gender ratio (M/F) of the population with elevated vitamin B12 levels was 0.5. 41 patients were aged ≥75 years (85.4%). The mean vitamin B12 level was 1,085 pg/mL (±428). 30 patients (62.5%) presented with moderate hypervitaminemia (<1,085 pg/mL), while 18 patients (37.5%) presented with elevated levels >1,085 pg/mL. Using the Chi2 or Fisher tests and the Student test, the factors with a significant link to hypervitaminemia B12 in univariate analysis were: acute renal failure (p=0.0002); liver diseases (p <0.0001) and solid neoplasia (p=0.0030). Using binary logistic regression for multivariate analysis, variables independently related to hypervitaminemia B12 were: acute renal failure: (odds ratio [OR]=6.3; 95%CI=2.7-8.1; p <0.0001); liver diseases (OR=5.4; 95%CI=3.1-6.9; p <0.0001); hematological disorders (OR=5.7; p=0.001); and age ≥75 years (OR=3.7; 95%CI=1.9-4.8; p=0.04). Moreover, there is an apparent correlation between rates of hypervitaminemia B12 and the number of etiologies identified (r=0.8; p=0.04). Our study confirm the significance of the link between hypervitaminemia B12 and hematological disorders in elderly patients, with a 5.7 fold higher risk.


hemopathy; hypervitaminemia B12; prognostic marker; renal failure; solid neoplasm

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