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Neurocase. 2017 Feb;23(1):52-59. doi: 10.1080/13554794.2017.1290807.

Functional brain alterations during self-reference processing in adolescents with sexual abuse-related post-traumatic stress disorder: A preliminary report.

Author information

1
a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
2
b CHU de Caen , Service de Psychiatrie de l'Enfant et de l'Adolescent , Caen , France.
3
c CHU de Rouen , Fédération hospitalo-universitaire de psychiatrie de l'enfant et de l'adolescent , Rouen , France.
4
d CHGR Rennes-I , Service de Psychiatrie de l'Enfant et de l'Adolescent , Rennes , France.

Abstract

We proposed to explore the functional brain changes during a self-reference processing (SRP) task in adolescents with sexual abuse-related post-traumatic stress disorder (N = 10), compared with healthy adolescents (N = 10). While patients showed no behavioral disturbances in (SRP), they exhibited changes in activity and connectivity in regions involved in emotional regulation (amygdala and dorsal prefrontal cortex) and semantic memory (temporal and ventrolateral prefrontal regions). These preliminary results suggest that these alterations may have an effect on self-esteem which may contribute to a possible retention and impairment of symptoms in adulthood.

KEYWORDS:

Post-traumatic stress disorder; amygdala; functional connectivity; functional magnetic resonance imaging; prefrontal

PMID:
28376696
DOI:
10.1080/13554794.2017.1290807
[Indexed for MEDLINE]

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