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J Rheumatol. 1988 Mar;15(3):475-8.

T cells are required for coxsackievirus B1 induced murine polymyositis.

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Department of Medicine, Minneapolis Veterans Administration Medical Center, MN 55417.


Murine polymyositis (PM) induced by coxsackievirus B1 (CVB1) has been used as a model of human PM. Our study was undertaken to investigate the role of T cells in CVB1 induced PM by examining disease development in neonatally thymectomized mice. Clinical weakness and histological inflammatory myositis occurred in 42.7% of sham operated animals but only 7.7% of thymectomized mice. These experiments demonstrate the importance of T cells in the pathogenesis of this virus induced autoimmune disorder.

[Indexed for MEDLINE]

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