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R I Med J (2013). 2017 Apr 3;100(4):29-32.

IgG4 Aortitis: A Case Report.

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Resident in Pathology, Rhode Island Hospital/ Alpert Medical School of Brown University, Providence, RI.
Pathologist, Rhode Island Hospital, Assistant Professor of Pathology and Laboratory Medicine (Clinical), Alpert Medical School of Brown University, Providence, RI.


IgG4 aortitis is one of the entities seen in the spectrum of IgG4-related disease (IgG4-RD). It is characterized by serologic (elevated serum IgG4) and histologic features including a lymphoplasmacytic infiltrate with increased numbers of IgG4-positive plasma cells, storiform fibrosis and obliterative phlebitis. Some studies have described a correlation between infections and IgG4 aortitis. We describe a patient with an aneurysm of the infrarenal descending abdominal aorta with features of IgG4-RD, as well as culture evidence of Streptococcus sanguis. [Full article available at].


IgG4; aortitis; plasma cells

[Indexed for MEDLINE]

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