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Pak J Pharm Sci. 2016 Nov;29(6):2047-2051.

Neuroprotective properties of Madecassoside from Centella asiatica after hypoxic-ischemic injury.

Author information

1
Department of Neurology, Qian Foshan Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
2
Department of Neurosurgery, Shandong Provincial Corps Hospital of Chinese People's Armed Police Force, Shandong Province, China.
3
Department of Neurology, Shandong Police General Hospital, Shandong Province, China.

Abstract

Madecassoside is one of increasingly used constituent of Centella asiatica, a frequently prescribed crude drug in South eastern Asia and China for wound healing. In the present experiment, it exposes the neuroprotective nature of Madecassoside in GT1-7 cell lines, further, which the antioxidant activities are performed. The cellular toxicity was assessed using 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay with increased cell viability with IC50 2.5µg/ml. the regulation of antioxidant levels showed changes in madecassoside treated cell lysate viz., SOD assay. Also, the antioxidative assays confirmed the negligible cellular damage caused to the GT1-7 cell lines. Hence, the results advocate that the current antioxidant and antitumor activity be justified by the high concentration of phenolic constituents, primarily the triterpene present in the C. asiatica.

PMID:
28375122
[Indexed for MEDLINE]

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