Format

Send to

Choose Destination
Trends Pharmacol Sci. 2017 Jun;38(6):556-568. doi: 10.1016/j.tips.2017.03.002. Epub 2017 Mar 31.

Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.

Author information

1
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
2
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: george.koob@nih.gov.

Abstract

Limited attention has been given to our understanding of how the brain responds to low-dose alcohol (ethanol) and what molecular and cellular targets mediate these effects. Even at concentrations lower than 10mM (0.046 g% blood alcohol concentration, BAC), below the legal driving limit in the USA (BAC 0.08 g%), alcohol impacts brain function and behavior. Understanding what molecular and cellular targets mediate the initial effects of alcohol and subsequent neuroplasticity could provide a better understanding of vulnerability or resilience to developing alcohol use disorders. We review here what is known about the neurobiology of low-dose alcohol, provide insights into potential molecular targets, and discuss future directions and challenges in further defining targets of low-dose alcohol at the molecular, cellular, and circuitry levels.

KEYWORDS:

alcohol; ethanol; intoxication; low-dose; molecular targets; neurobiology

PMID:
28372826
PMCID:
PMC5597438
DOI:
10.1016/j.tips.2017.03.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center