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J Pathol Transl Med. 2017 May;51(3):320-324. doi: 10.4132/jptm.2016.09.07. Epub 2017 Apr 4.

Unusual Histology of Eosinophilic Myenteric Ganglionitis: A Case Report.

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Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
Department of Radiology, Eulji University School of Medicine, Daejeon, Korea.
Department of Surgery, Eulji University School of Medicine, Daejeon, Korea.


Eosinophilic myenteric ganglionitis is a disorder characterized by infiltration of the Auerbach myenteric plexus by eosinophils. As a cause of chronic intestinal pseudo-obstruction (CIPO), eosinophilic myenteric ganglionitis has been rarely reported and the majority of the reported cases in the literature were children. We experienced a case of eosinophilic myenteric ganglionitis associated with CIPO in a 53-year-old female patient. Histologic examination of the resected descending colon showed moderate eosinophilic infiltrates with hypogangliosis in the myenteric plexus. Immunohistochemical study revealed increased number of CD4-positive lymphocytes and stronger but scantier glial fibillary acid protein expression in the inflamed myenteric plexus.


Eosinophils; Ganglionitis; Pseudo-obstruction

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