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J Vet Intern Med. 2017 May;31(3):678-684. doi: 10.1111/jvim.14690. Epub 2017 Mar 31.

Association between Survival Time and Changes in NT-proBNP in Cats Treated for Congestive Heart Failure.

Author information

1
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.

Abstract

BACKGROUND:

Reductions in N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations after treatment have been associated with improved survival in people with congestive heart failure (CHF), but have not been reported in cats with CHF.

OBJECTIVES:

To evaluate changes in NT-proBNP concentrations in cats with CHF after treatment and determine whether serial NT-proBNP measurements provide prognostic information.

ANIMALS:

Thirty-one client-owned cats.

METHODS:

Prospective, observational study in cats with new onset CHF secondary to cardiomyopathy. Concentrations of NT-proBNP were measured within 4 hours of admission to the hospital, on the day of discharge, and at re-evaluation 7-10 days later.

RESULTS:

Median NT-proBNP concentrations decreased significantly from admission (1,713 pmol/L [range, 160-3,784 pmol/L]) to discharge (902 pmol/L [range, 147-3,223 pmol/L]); P = .005) and from admission to re-evaluation (1,124 pmol/L [range, 111-2,727 pmol/L]; P = .024). Median survival time was 109 days (range, 1-709 days), with 5 cats still alive at the time of analysis. Cats with a larger percent decrease in NT-proBNP from admission to discharge had a longer survival time (P = .048). Cats with evidence of active CHF at the time of re-evaluation (P = .010) and cats whose owners had difficulty administering medications (P = .045) had shorter survival times.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Cats with a larger percent decrease in NT-proBNP during hospitalization and no evidence of CHF at the time of re-evaluation had longer survival times. Additional studies are needed to determine whether NT-proBNP can help guide treatment in cats with CHF.

KEYWORDS:

Biomarker; Cardiomyopathy; Feline; Prognosis

PMID:
28370373
PMCID:
PMC5435051
DOI:
10.1111/jvim.14690
[Indexed for MEDLINE]
Free PMC Article

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