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Autophagy. 2017 Apr 3;13(4):763-764. doi: 10.1080/15548627.2017.1280221. Epub 2017 Feb 22.

Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice.

Author information

1
a Department of Biochemistry and Molecular Biology , Graduate School and Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
2
b Japan Science and Technology Agency , PRESTO , Saitama , Japan.

Abstract

Atg5-null mice are neonatal lethal. We have revealed in our recent paper that these mice die due to neuronal dysfunction resulting in suckling failure. Our new mouse model, atg5-/-;Eno2/Nse-Atg5 mice, where Atg5 is deficient in the whole body except for neurons, enables us to analyze the consequences of macroautophagy/autophagy-deficiency in the whole body of adult mice.

KEYWORDS:

ATG5; autophagy deficiency; hypogonadism; iron deficiency; neonatal lethality; neuronal dysfunction; suckling failure; systemic analysis

PMID:
28368776
PMCID:
PMC5388233
DOI:
10.1080/15548627.2017.1280221
[Indexed for MEDLINE]
Free PMC Article

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