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Nat Prod Res. 2018 Feb;32(4):430-434. doi: 10.1080/14786419.2017.1308363. Epub 2017 Apr 3.

Pyranocarbazoles from Murraya koenigii (L.) Spreng. as antimicrobial agents.

Author information

1
a Sophisticated Analytical Instrument Facility , CSIR-Central Drug Research Institute , Lucknow , India.
2
b Molecular and Structural Biology Division , CSIR-Central Drug Research Institute , Lucknow , India.
3
e Academy of Scientific and Innovative Research , India.
4
c Botany Division , CSIR-Central Drug Research Institute , Lucknow , India.
5
d Division of Pharmacokinetics and Metabolism , CSIR-Central Drug Research Institute , Lucknow , India.

Abstract

The bioassay guided fractionation of methanolic extract of Murraya koenigii (L.) Spreng. leaves resulted in the isolation of seven pyranocarbazoles. These were evaluated against four bacterial strains and ten Candida sp. including two matched pair of fluconazole sensitive/resistant clinical isolates. Out of seven, three i.e. Koenine (mk279), Koenigine (mk309) and Mahanine (mk347) exhibited significant antibacterial activity MIC90 3.12-12.5 μg/mL against bacterial strains Streptococcus aureus and Klebsiella pneumonia compared with standard drug Kanamycin MIC90 12.5 μg/mL. However, only mk309 was found active against variety of Candida species MIC90 12.5-100 μg/mL. It was observed that hydroxylation at C-6 and C-7 positions in the studied pyranocarbazoles activate the bioactivity. Simultaneously, decrease in Log P value compares with -H and -O-CH3 substituted derivatives. The study is focused on selective antifungal and antibacterial activity of pyranocarbazoles on bacterial strains S. aureus, K. pneumonia and variety of Candida species with structure activity relationship observations.

KEYWORDS:

Klebsiella pneumonia; Pyranocarbazoles; Streptococcus aureus; antibacterial; antifungal; carbazole alkaloids

PMID:
28368664
DOI:
10.1080/14786419.2017.1308363
[Indexed for MEDLINE]

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