Format

Send to

Choose Destination
J Clin Invest. 2017 Apr 3;127(4):1202-1214. doi: 10.1172/JCI88894. Epub 2017 Apr 3.

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

Abstract

Peroxisome proliferator-activated receptors (PPARs) regulate energy metabolism and hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. While they share anti-inflammatory activities, the PPAR isotypes distinguish themselves by differential actions on lipid and glucose homeostasis. In this Review we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the underlying cellular and molecular mechanisms, as well as the synthetic PPAR ligands that are used in the clinic or under development. We highlight the potential of new PPAR ligands with improved efficacy and safety profiles in the treatment of complex metabolic disorders.

PMID:
28368286
PMCID:
PMC5373878
DOI:
10.1172/JCI88894
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center