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J Orthop. 2017 Mar 20;14(2):252-256. doi: 10.1016/j.jor.2017.03.003. eCollection 2017 Jun.

BMP-2-induced bone formation and neural inflammation.

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Department of Pathology, Johns Hopkins University, 21205, United States.
Department of Surgery, University of Michigan, 48109, United States.


Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.


Bone morphogenetic protein; Inflammation; Neural inflammation; Neuritis; Osteogenesis; Skeletal engineering

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