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Immunol Allergy Clin North Am. 2017 May;37(2):283-299. doi: 10.1016/j.iac.2017.01.005. Epub 2017 Mar 1.

Biologic Therapies for Autoimmune and Connective Tissue Diseases.

Author information

1
Section on Rheumatology and Immunology, Wake Forest Baptist Health, Medical Center Boulevard, Winston Salem, NC 27157, USA.
2
Section on Rheumatology and Immunology, Wake Forest Baptist Health, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address: dang@wakehealth.edu.

Abstract

Biologic therapy continues to revolutionize the treatment of autoimmune disease, especially in rheumatology as the pathophysiology of both inflammation and autoimmune disease becomes better understood. These therapies are designed to dampen the response of the inflammatory cascades. Although the first biologic therapies were approved many years ago, expanding indications and new agents continue to challenge the traditional treatment strategies for rheumatic diseases. This article reviews the data supporting the current use of biologic therapies, including off-label indications, in a subset of rheumatic diseases including rheumatoid arthritis, lupus, inflammatory myositis, ankylosing spondylitis, psoriatic arthritis, vasculitis, and gout.

KEYWORDS:

Ankylosing spondylitis; Biologic therapy; Gout; Lupus; Psoriatic arthritis; Rheumatoid arthritis

PMID:
28366477
DOI:
10.1016/j.iac.2017.01.005
[Indexed for MEDLINE]

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