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J Pediatr. 2017 Aug;187:141-146.e1. doi: 10.1016/j.jpeds.2017.03.007. Epub 2017 Mar 30.

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.

Collaborators (175)

Abrams SH11, Barlow S11, Himes R11, Krisnamurthy R11, Maldonado L11, Mahabir R11, Carr A12, Bernstein K12, Bramlage K12, Cecil K12, DeVore S12, Kohli R12, Lake K12, Podberesky D12, Towbin A12, Xanthakos S12, Allende D13, Dasarathy S13, McCullough AJ13, Pagadala M13, Pai R13, Winston C13, Behr G14, Lavine JE14, Lefkowitch JH14, Mencin A14, Reynoso E14, Abdelmalek MF15, Bashir M15, Buie S15, Diehl AM15, Guy C15, Kigongo C15, Malik D15, Pan YP15, Piercy D15, Kopping M15, Thrasher T15, Alazraki A16, Cleeton R16, Cordero M16, Hernandez A16, Karpen S16, Munos JC16, Raviele N16, Vos M16, Bozic M17, Chalasani N17, Cummings OW17, Gawrieh S17, Klipsch A17, Molleston JP17, Ragozzino E17, Ragozzino L17, Sandrasegaran K17, Subbarao G17, Vuppalanchi R17, Walker L17, Kafka K18, Scheimann A18, Ito J19, Fishbein MH19, Mohammad S19, Rigsby C19, Sharda L19, Whitington PF19, Barlow S20, Cattoor T20, Derdoy J20, Freebersyser J20, Jain A20, King D20, Lai J20, Osmack P20, Siegner J20, Stewart S20, Neuschwander-Tetri BA20, Torretta S20, Wriston K20, Assadian F21, Barone V21, Gonzalez MC21, Davila J21, Fix O21, Hennessey KA21, Kowdley KV21, Lopez K21, Ness E21, Poitevin M21, Procaccini N21, Quist B21, Saddic A21, Wiseman C21, Yeh M21, Baker SS22, Lopez-Graham D22, Williams S22, Zhu L22, Africa J23, Ang B23, Awai H23, Behling C23, Bhatt A23, Bross C23, Collins J23, Durelle J23, Harlow K23, Loomba R23, Middleton M23, Newton K23, Paiz M23, Schwimmer JB23, Sirlin C23, Ugalde-Nicalo P23, Villarreal MD23, Aouizerat B24, Bass NM24, Brandman D24, Courtier J24, Ferrell LD24, Feier N24, Gill R24, Hameed B24, Langlois C24, Maher J24, Perito ER24, Ramos C24, Rosenthal P24, Terrault N24, Tsai P24, Ungermann A24, Atla P25, Croft B25, Garcia R25, Garcia S25, Sheikh M25, Singh M25, Cooper K26, Horslen S26, Hsu E26, Murray K26, Otto R26, Yeh M26, Young M26, Boyett S27, Carucci L27, Contos MJ27, Kirwin S27, Kraft K27, Luketic VAC27, Puri P27, Sanyal AJ27, Schlosser J27, Siddiqui MS27, Brunt EM28, Fowler K28, Kleiner DE29, Brown S30, Doo EC30, Hoofnagle JH30, Robuck PR30, Sherker A30, Torrance R30, Belt P31, Clark JM31, Donithan M31, Hallinan E31, Isaacson M31, May KP31, Miriel L31, Sternberg A31, Tonascia J31, Van Natta M31, Wilson L31, Yates K31.

Author information

1
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Division of Gastroenterology, Department of Pediatrics, Rady Children's Hospital, San Diego, CA.
2
Division of Dysmorphology and Teratology, Department of Pediatrics, University of California San Diego, La Jolla, CA.
3
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD.
4
Department of Pathology, Sharp Medical Center, San Diego, CA.
5
Department of Pediatrics, Riley Children's Hospital, Indianapolis, IN.
6
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
7
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA.
8
Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
9
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University, New York, NY.
10
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA; Division of Gastroenterology, Department of Pediatrics, Rady Children's Hospital, San Diego, CA. Electronic address: jschwimmer@ucsd.edu.
11
Baylor College of Medicine, Houston, TX.
12
Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
13
Cleveland Clinic Foundation, Cleveland, OH.
14
Columbia University, New York, NY.
15
Duke University Medical Center, Durham, NC.
16
Emory University, Atlanta, GA.
17
Indiana University School of Medicine, Indianapolis, IN.
18
Johns Hopkins Hospital, Baltimore, MD.
19
Northwestern University Feinberg School of Medicine/Ann & Robert H. Lurie Children's Hospital of Chicago.
20
Saint Louis University, St Louis, MO.
21
Swedish Medical Center, Seattle, WA.
22
University at Buffalo, Buffalo, NY.
23
University of California San Diego, San Diego, CA.
24
University of California San Francisco, San Francisco, CA.
25
University of California San Francisco- Fresno, Fresno, CA.
26
University of Washington Medical Center and Seattle Children's Hospital, Seattle, WA.
27
Virginia Commonwealth University, Richmond, VA.
28
Washington University, St. Louis, MO.
29
National Cancer Institute, Bethesda, MD.
30
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
31
Johns Hopkins University, Bloomberg School of Public Health (Data Coordinating Center), Baltimore, MD.

Abstract

OBJECTIVES:

To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD.

STUDY DESIGN:

A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category.

RESULTS:

Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62).

CONCLUSION:

Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

KEYWORDS:

birth weight; children; epidemiology; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; obesity

PMID:
28366357
PMCID:
PMC5533631
DOI:
10.1016/j.jpeds.2017.03.007
[Indexed for MEDLINE]
Free PMC Article

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