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BMB Rep. 2017 Jun;50(6):299-307.

Emerging role of mitophagy in human diseases and physiology.

Author information

1
Department of Biochemistry, and Peripheral Neuropathy Research Center, College of Medicine, Dong-A University, Busan 49201, Korea.

Abstract

Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology. [BMB Reports 2017; 50(6): 299-307].

PMID:
28366191
PMCID:
PMC5498140
[Indexed for MEDLINE]
Free PMC Article

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