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Vaccine. 2017 Apr 25;35(18):2404-2412. doi: 10.1016/j.vaccine.2017.03.036. Epub 2017 Mar 30.

Semiconductor diode laser device adjuvanting intradermal vaccine.

Author information

1
Vaccine and Immunotherapy Center, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, United States.
2
SemiNex Corporation, 100 Corporate Place, Suite 401, Peabody, MA 01960, United States.
3
SemiNex Corporation, 100 Corporate Place, Suite 401, Peabody, MA 01960, United States; Veralase LLC, 135 East Street, Middleton, MA 01949, United States.
4
Graduate School of Fundamental Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
5
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States.
6
SemiNex Corporation, 100 Corporate Place, Suite 401, Peabody, MA 01960, United States; Veralase LLC, 135 East Street, Middleton, MA 01949, United States. Electronic address: dbean@veralase.com.
7
Vaccine and Immunotherapy Center, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, United States. Electronic address: skashiwagi@mgh.harvard.edu.

Abstract

A brief exposure of skin to a low-power, non-tissue damaging laser light has been demonstrated to augment immune responses to intradermal vaccination. Both preclinical and clinical studies show that this approach is simple, effective, safe and well tolerated compared to standard chemical or biological adjuvants. Until now, these laser exposures have been performed using a diode-pumped solid-state laser (DPSSL) devices, which are expensive and require labor-intensive maintenance and special training. Development of an inexpensive, easy-to-use and small device would form an important step in translating this technology toward clinical application. Here we report that we have established a handheld, near-infrared (NIR) laser device using semiconductor diodes emitting either 1061, 1258, or 1301nm light that costs less than $4000, and that this device replicates the adjuvant effect of a DPSSL system in a mouse model of influenza vaccination. Our results also indicate that a broader range of NIR laser wavelengths possess the ability to enhance vaccine immune responses, allowing engineering options for the device design. This small, low-cost device establishes the feasibility of using a laser adjuvant approach for mass-vaccination programs in a clinical setting, opens the door for broader testing of this technology with a variety of vaccines and forms the foundation for development of devices ready for use in the clinic.

KEYWORDS:

Adjuvant; Handheld; Laser; Near-infrared; Semiconductor laser diode; Vaccine

PMID:
28365253
PMCID:
PMC5576344
DOI:
10.1016/j.vaccine.2017.03.036
[Indexed for MEDLINE]
Free PMC Article

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