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Maturitas. 2017 May;99:105-108. doi: 10.1016/j.maturitas.2017.02.015. Epub 2017 Feb 28.

Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study.

Author information

1
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. Electronic address: ampedraza@isciii.es.
2
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain.
3
Aragon Breast Cancer Screening Program, Health Service of Aragon, Zaragoza, Spain.
4
Navarra Breast cancer Screening Program, Public Health Institute, Pamplona, Spain.
5
Valencia Breast Cancer Screening Program, General Directorate Public Health, Valencia, Spain.
6
Cancer Prevention and Control Unit, Catalan Institute of Oncology (ICO), Barcelona, Spain.
7
Balearic Islands Breast Cancer Screening Program, Health Promotion for Women and Childhood, General Directorate Public Health and Participation, Regional Authority of Health and Consumer Affairs, Balearic Islands, Palma de Mallorca, Spain.
8
Galicia Breast Cancer Screening Program, Regional Authority of Health, Galicia Regional Government, Corunna, Spain.
9
Castile-Leon Breast Cancer Screening Program, General Directorate Public Health SACYL, Burgos, Castile-Leon, Spain.
10
Institute of Computer Technology, Universitat Politècnica de València, Spain.
11
Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain. Electronic address: bperez@isciii.es.

Abstract

We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characteristics. Two radiologists assessed MD in their left craneo-caudal mammogram, assisted by a validated semiautomatic-computer tool (DM-scan). We used log-transformed percentage MD as the dependent variable and fitted mixed linear regression models, including known confounding variables. Our results showed that neither sleeping patterns nor sleep disorders were associated with MD. However, women with frequent changes in their bedtime due to anxiety or depression had higher MD (eβ:1.53;95%CI:1.04-2.26).

KEYWORDS:

Breast cancer; Mammographic density; Sleep disorders; Sleep patterns

PMID:
28364862
DOI:
10.1016/j.maturitas.2017.02.015
[Indexed for MEDLINE]

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