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Eur Arch Otorhinolaryngol. 2017 Jul;274(7):2709-2726. doi: 10.1007/s00405-017-4533-8. Epub 2017 Mar 31.

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Author information

1
Department of Otolaryngology, Hospital Universitario Central de Asturias, Avenida de Roma s/n, 33011, Oviedo (Asturias), Spain. flopez_1981@yahoo.es.
2
Instituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo, Oviedo, Spain. flopez_1981@yahoo.es.
3
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
4
Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain.
5
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
6
Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia.
7
University of Udine School of Medicine, Udine, Italy.
8
Departments of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh, UK.
9
Department of Otolaryngology, Hospital Universitario Central de Asturias, Avenida de Roma s/n, 33011, Oviedo (Asturias), Spain.
10
Instituto Universitario de Oncología del Principado de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias and CIBERONC, ISCIII, University of Oviedo, Oviedo, Spain.
11
Department of Hematology and Medical Oncology, The Winship Cancer Institute of Emory University, Atlanta, GA, USA.
12
Department of Radiation Oncology, University of Florida, Gainesville, FL, USA.
13
Department of Otolaryngology, Hospital Santa Creu i Sant Pau, Barcelona, Spain.
14
International Head and Neck Scientific Group, Padua, Italy.

Abstract

Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Because a spectrum of disease biology is represented by these rare phenotypes, an understanding of the basic biology can help direct management to optimize clinical outcome in this group of patients. This review provides a critical analysis of literature relating to the diagnosis, management, and outcome of patients with non-conventional squamous malignant epithelial neoplasms of the larynx. Particular attention is paid to features which are at variance with the conventional SCC and how these impact on management of these rare tumors.

KEYWORDS:

Acantholytic squamous cell carcinoma; Adenosquamous carcinoma larynx; Basaloid squamous cell carcinoma; Histology; Laryngeal cancer; Lymphoepithelial carcinoma; Non-keratinizing HPV-positive squamous cell carcinoma; Papillary squamous cell carcinoma; Spindle cell carcinoma; Verrucous squamous cell carcinoma

PMID:
28364287
DOI:
10.1007/s00405-017-4533-8
[Indexed for MEDLINE]

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