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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Mar 28;42(3):340-345. doi: 10.11817/j.issn.1672-7347.2017.03.017.

[Role of cannabinoid receptor 1-mediated synaptic plasticity in neuropathic pain and associated depression].

[Article in Chinese; Abstract available in Chinese from the publisher]

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Department of Anethesiology, Jinling Hospital, Medical School of Nanjing University/Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002, China.
Department of Anethesiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.


in English, Chinese

Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain, allodynia, and hyperalgesia. It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain. Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission, regulates synaptic plasticity, inhibits central sensitization, and thus attenuates neuropathic pain. Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression.

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