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J Neurotrauma. 2017 Mar 31. doi: 10.1089/neu.2016.4729. [Epub ahead of print]

The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration to Accelerate Diagnosis and Treatment of Traumatic Brain Injury.

Author information

1
University of California, San Francisco, Neurological Surgery , 1001 Potrero Avenue , Building 1, Room 101 , San Francisco, California, United States , 94110 ; manleyg@neurosurg.ucsf.edu.
2
Seattle, Washington, United States ; cmacd@uw.edu.
3
University of California, San Francisco, Neurological Surgery, San Francisco, California, United States ; amy.markowitz@ucsf.edu.
4
Critical Path Institute , Tucson, Arizona, United States ; DStephenson@c-path.org.
5
Critical Path Institute , Tucson, Arizona, United States ; Arobbins@c-path.org.
6
UCSF and San Francisco VA Medical Center, Neurology, San Francisco, California, United States ; raquel.gardner@ucsf.edu.
7
University of Califonia San Francisco, Neurological Surgery , 1001 Potrero Avenue , Building 1, Room 101 , San Francisco, California, United States , 94110 ; ethan.winkler@ucsf.edu.
8
Spaulding Rehabilitation Hospital, 24498, Charlestown, Massachusetts, United States ; ybodien@partners.org.
9
UCSF, San Francisco, California, United States ; srtaylor@partners.org.
10
University of California, San Francisco, Neurological Surgery , 1001 Potrero Avenue , Bldg 1, Rm 101 , San Francisco, California, United States , 94110.
11
San Francisco General Hospital, 36558, Brain and Spinal Injury Center , 1001 Potrero Avenue , Bldg 1, Rm 101 , San Francisco, California, United States , 94110 ; john.yue@ucsf.edu.
12
US Food and Drug Administration, 4137, Silver Spring, Maryland, United States ; Lakshmi.Kannan@fda.hhs.gov.
13
San Francisco, California, United States ; allimk3@gmail.com.
14
Medical College of Wisconsin, Neurosurgery, Milwaukee, Wisconsin, United States ; mmccrea@mcw.edu.
15
University of Florida, Psychiatry , 1149 Newell Drive , L4-100 , Gainesville, Florida, United States , 32611 ; kawangwang17@gmail.com.

Abstract

The Traumatic Brain Injury Endpoints Development (TED) Initiative is a 5-year, Department of Defense (DoD) funded project that is working toward the ultimate goal of developing better designed clinical trials, leading to more precise diagnosis, and effective treatments for traumatic brain injury (TBI). TED is comprised of leading academic clinician-scientists, along with innovative industry leaders in biotechnology and imaging technology, patient advocacy organizations, and philanthropists, working collaboratively with regulatory authorities, specifically the US Food and Drug Administration (FDA). The goals of the TED Initiative are to gain consensus and validation of TBI clinical outcome assessment measures and biomarkers for endorsement by global regulatory agencies for use in drug and device development processes. This manuscript summarizes the Initiative's Stage 1 progress over the first 18 months, including intensive engagement with a number of FDA divisions responsible for review and validation of biomarkers and clinical outcome assessments, progression into the prequalification phase of FDA's Medical Device Development Tool program for a candidate set of neuroimaging biomarkers, and receipt of FDA's Recognition of Research Importance Letter regarding TBI. Other signal achievements relate to the creation of the TED Metadataset, harmonizing study measures across eight major TBI studies, and the leadership role played by TED investigators in the conversion of the NINDS TBI Common Data Elements (CDEs) to Clinical Data Interchange Standards Consortium (CDISC) standards. This paper frames both the near-term expectations and the Initiative's long-term vision to accelerate approval of treatments for patients affected by TBI in urgent need of effective therapies.

KEYWORDS:

BIOMARKERS; CT SCANNING; MRI; OUTCOME MEASURES; TRAUMATIC BRAIN INJURY

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