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J Nat Prod. 2017 Apr 28;80(4):1215-1228. doi: 10.1021/acs.jnatprod.6b00235. Epub 2017 Mar 31.

Antibacterial Compounds from Marine Bacteria, 2010-2015.

Author information

1
Department of Food Science, School of Food Engineering, University of Campinas , Campinas-SP, CEP 13083-862, Brazil.
2
Brazilian Agricultural Research Corporation , Rodovia SP-340 km 127.5, Jaguariúna-SP, CEP 13820-000, Brazil.

Abstract

This review summarizes the reports on antibacterial compounds that have been obtained from marine-derived bacteria during the period 2010-2015. Over 50 active compounds were isolated during this period, most of which (69%) were obtained from Actinobacteria. Several compounds were already known, such as etamycin A (11) and nosiheptide (65), and new experiments with them showed some previously undetected antibacterial activities, highlighting the fact that known natural products may be an important source of new antibacterial leads. New broad-spectrum antibacterial compounds were reported with activity against antibiotic resistant Gram-positive and Gram-negative bacteria. Anthracimycin (33), kocurin (66), gageotetrins A-C (72-74), and gageomacrolactins 1-3 (86-88) are examples of compounds that display promising properties and could be leads to new antibiotics. A number of microbes produced mixtures of metabolites sharing similar chemical scaffolds, and structure-activity relationships are discussed.

PMID:
28362500
DOI:
10.1021/acs.jnatprod.6b00235
[Indexed for MEDLINE]

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