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Nutr Cancer. 2017 May-Jun;69(4):593-600. doi: 10.1080/01635581.2017.1299873. Epub 2017 Mar 31.

Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population.

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a School of Public Health, Central South University , Changsha , Hunan , China.
b Department of Preventive Medicine , Changzhi Medical College , Changzhi , China.
c Central Laboratory , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
d Department of Oncology , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
e Henan Key Laboratory for Esophageal Cancer Research, Zhengzhou University , Zhengzhou , China.


Experimental studies have determined the chemopreventive effects of vitamin D against the esophageal squamous cell carcinoma (ESCC); however, results from the epidemiological studies are not yet well established. The current study aimed to evaluate the associations between plasma vitamin D levels and variants on vitamin D metabolic-related genes with the risks for ESCC. A hospital-based case-control study was performed. Five hundred eighty-two ESCC patients and 569 controls were recruited in a Northern Chinese population. Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined. The unconditional logistic regression method was applied to determine the associations between the variants and vitamin D level and ESCC. Higher plasma 25(OH)D was associated with a reduced risk for ESCC, especially for rs2296241, rs11568820, and rs4646536. The variants rs2296241 on CYP24A1 and rs11568820 on VDR are significantly associated with ESCC cancer. Vitamin D signaling pathways may participate in the ESCC development. Further studies with larger sample size are warranted to confirm the results. Intervention studies are needed to determine whether vitamin D supplementation may reduce the ESCC risk in the Chinese population.

[Indexed for MEDLINE]

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