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Nat Cell Biol. 2017 Mar 31;19(4):265-267. doi: 10.1038/ncb3501.

Talin gets SHANKed in the fight for integrin activation.

Author information

1
the Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.

Abstract

Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.

PMID:
28361943
DOI:
10.1038/ncb3501
[Indexed for MEDLINE]

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