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Nat Cell Biol. 2017 Mar 31;19(4):263-265. doi: 10.1038/ncb3504.

PARL paves the way to apoptosis.

Author information

1
Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume 839-0864, Japan.
2
Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.

Abstract

Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.

PMID:
28361942
DOI:
10.1038/ncb3504
[Indexed for MEDLINE]

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