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J Clin Orthop Trauma. 2017 Jan-Mar;8(1):85-88. doi: 10.1016/j.jcot.2016.09.008. Epub 2016 Sep 30.

Intra-articular hyaluronic acid is superior to steroids in knee osteoarthritis: A comparative, randomized study.

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Department of Orthopaedics and Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi 110076, India.



To compare the short and mid-term results of intraarticular triamcinolone hexacetonide and hyaluronic acid (HA) in knee osteoarthritis.


A prospective randomized study including 40 patients in steroid and 42 patients in HA group. The outcome was evaluated with Knee Society Score (KSS) and Visual Analog Scale (VAS).


On KSS function and VAS score, there was no difference till four weeks. On KSS pain there was no difference till 12 weeks (P > 0.05) after that score of steroid group deteriorated rapidly. At six months HA was significantly better than a steroid.


The HA seems to be better for pain relief and functionality in the short and mid-term periods.


Hyaluronic acid; Intra-articular; Knee Society Score; Osteoarthritis; Steroid

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