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Arterioscler Thromb Vasc Biol. 2017 May;37(5):764-777. doi: 10.1161/ATVBAHA.117.308611. Epub 2017 Mar 30.

ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.

Author information

1
From the Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, CA (K.L., H.W.); Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Germany (N.G.); and Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU), Munich, Germany (N.G.). klaus@lji.org.
2
From the Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, CA (K.L., H.W.); Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Germany (N.G.); and Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU), Munich, Germany (N.G.).

Abstract

OBJECTIVE:

Immune cells play a critical role in atherosclerosis. Costimulatory and coinhibitory molecules of the tumor necrosis factor receptor and CD28 immunoglobulin superfamilies not only shape T-cell and B-cell responses but also have a major effect on antigen-presenting cells and nonimmune cells.

APPROACH AND RESULTS:

Pharmacological inhibition or activation of costimulatory and coinhibitory molecules and genetic deletion demonstrated their involvement in atherosclerosis. This review highlights recent advances in understanding how costimulatory and coinhibitory pathways shape the immune response in atherosclerosis.

CONCLUSIONS:

Insights gained from costimulatory and coinhibitory molecule function in atherosclerosis may inform future therapeutic approaches.

KEYWORDS:

B-lymphocytes; antigen-presenting cells; atherosclerosis; immunoglobulins; receptors, tumor necrosis factor

PMID:
28360089
PMCID:
PMC5424816
DOI:
10.1161/ATVBAHA.117.308611
[Indexed for MEDLINE]
Free PMC Article

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