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Mar Drugs. 2017 Mar 30;15(4). pii: E103. doi: 10.3390/md15040103.

From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.

Author information

1
Venomics Research Group, BGI-Shenzhen, Shenzhen 518083, China. xiebing@genomics.cn.
2
Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI, Shenzhen 518083, China. huangyu@genomics.cn.
3
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. kate.baumann@uqconnect.edu.au.
4
Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. bgfry@uq.edu.au.
5
Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI, Shenzhen 518083, China. shiqiong@genomics.cn.
6
BGI Shenzhen Academy of Marine Sciences, BGI Fisheries, BGI, Shenzhen 518083, China. shiqiong@genomics.cn.

Abstract

The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), it has been much easier and faster to identify more toxins and predict their functions with bioinformatics pipelines, which pave the way for novel drug developments. Here we provide an overview of related bioinformatics pipelines that have been supported by a combination of transcriptomics and proteomics for identification and function prediction of novel marine toxins.

KEYWORDS:

database; marine toxins; proteome; transcriptome; venomics

PMID:
28358320
PMCID:
PMC5408249
DOI:
10.3390/md15040103
[Indexed for MEDLINE]
Free PMC Article

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