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Microb Cell. 2016 Jun 20;3(7):296-298. doi: 10.15698/mic2016.07.514.

Antibiotic use in childhood alters the gut microbiota and predisposes to overweight.

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Department of Bacteriology and Immunology, Immunobiology Research Program, University of Helsinki, Finland.


A correlation between the use of antibiotics in early life and the excessive weight gain in later childhood has been shown in several large cohort studies all over the world. One hypothesis explaining this association is the pervasive impact that antibiotics may have on the intestinal microbiota, and this has been supported by recent mouse studies. Studies have shown dramatic changes in the intestinal microbiota of adults in response to oral antibiotic treatments. However, little is known about the impact of antibiotics on the intestinal microbiota of children, although antibiotics account for the majority of the medication prescribed to children in Western countries.


amoxicillin; antibiotics; asthma; bile salt hydrolase; child; macrolide; microbiota; obesity

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Conflict of interest: The authors declare that no competing interest exists.

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