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Sci Transl Med. 2017 Mar 29;9(383). pii: eaan3022. doi: 10.1126/scitranslmed.aan3022.

Macrophages take rheumatoid arthritis up a "Notch".

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1
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA. Email: blevi@umich.edu.

Abstract

Notch signaling in bone marrow-derived inflammatory macrophages is central to synovial inflammation seen in rheumatoid arthritis, representing a promising future therapeutic target.

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