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Infect Disord Drug Targets. 2018;18(2):88-95. doi: 10.2174/1871526517666170329123845.

Role of Chirality in Drugs: An Overview.

Author information

1
Department of Pharmaceutical Chemistry & Drug Control, Faculty of Pharmacy, Arab International University, Syrian Arab Republic.
2
Department of Chemistry, Faculty of Science, Damascus University, Syrian Arab Republic.

Abstract

Stereochemistry has occupied a great role in the manufacture and development of pharmaceuticals. Chiral properties play an important role in the determination of pharmacological actions of the drug. In recent years, there is a considerable interest in chiral separation to isolate and examine both enantiomers. This article provides an overview about the stereochemistry and its role in drugs, and also, offers approved isolation methods for enantiomeric pairs.

KEYWORDS:

Chirality; chiral drug; chiral separation; enantiomer; pharmacology; stereoisomer.

[Indexed for MEDLINE]

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