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Pediatr Res. 2017 Jul;82(1):63-71. doi: 10.1038/pr.2017.77. Epub 2017 May 24.

Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial.

Author information

1
Department of Clincial Sciences, Pediatrics, Umeå University, Umeå, Sweden.
2
Arla Foods Ingredients, Viby, Denmark.
3
Department of Nutrition, University of California, Davis, California.
4
Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
5
Department of Pediatrics, Fudan University, Shanghai, China.

Abstract

BackgroundHuman milk is rich in osteopontin (OPN), which has immunomodulatory functions.MethodsIn a randomized controlled trial, standard formula (SF) and the same formula with 65 mg of OPN/L (F65) or 130 mg of OPN/L (F130), representing ~50 and 100% of the OPN concentration in human milk, were compared. We examined frequencies and composition of peripheral blood immune cells by four-color immunoflow cytometry of formula-fed infants at ages 1, 4, and 6 months, and compared them with a breastfed (BF) reference group.ResultsThe F130 group had increased T-cell proportions compared with the SF (P=0.036, average effect size 0.51) and F65 groups (P=0.008, average effect size 0.65). Compared with the BF group, the monocyte proportions were increased in the F65 (P=0.001, average effect size 0.59) and F130 (P=0.006, average effect size 0.50) groups, but were comparable among the formula groups.ConclusionOPN in an infant formula at a concentration close to that of human milk increased the proportion of circulating T cells compared with both SF and formula with added OPN at ~50% of the concentration in human milk. This suggests that OPN may favorably influence immune ontogeny in infancy and that the effects appear to be dose-dependent.

PMID:
28355198
DOI:
10.1038/pr.2017.77
[Indexed for MEDLINE]

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