The enlarged parotid glands seen in both poor nutritional states and in women with amenorrhea have always been considered to be separate entities. Thirteen observations are reported of a syndrome consisting of dysorexia (or anorexia), swelling of the salivary glands (sialomegaly), and menstrual disturbances (hypomenorrhea or amenorrhea). This syndrome can be defined as a clinical entity combining the symptomatology of parotid enlargements due to poor nutrition and those caused by sex-hormone disorders. In the Dysorexia-Sialomegaly-Amenorrhea syndrome, the salivary gland swellings are due to poor nutrition and the amenorrhea, which is of the hypothalamic type, is also secondary to poor nutrition.