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Hypoxia (Auckl). 2017 Mar 15;5:11-20. doi: 10.2147/HP.S127042. eCollection 2017.

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

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Target Discovery Institute, University of Oxford; The Francis Crick Institute, London, UK.
Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, Canada.
Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Department of Radiation Oncology, Duke University School of Medicine, Durham, NC, USA.
INSERM UMR 1229, Regenerative Medicine and Skeleton-RMeS, Team STEP, University of Nantes, UFR Odontology.
UMR 1238 INSERM, Université de Nantes, Faculté de Médecine.
CRCINA, INSERM, Université de Nantes, Nantes.
CRCINA, INSERM, Université de Nantes, Nantes; Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France.


The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in Nantes, France, in October 6-7, 2016. The main objective of this conference was to bring together a large group of scientists from different spheres of hypoxia. Recent advances were presented and discussed around different topics: genomics, physiology, musculoskeletal, stem cells, microenvironment and cancer, and oxidative stress. This review summarizes the major highlights of the meeting.


cancer; genomics; hypoxia; lipid metabolism; musculoskeletal; oxidative stress

Conflict of interest statement

Disclosure IBH is a consultant with BioMimetix JVLLC and holds equities in BioMimetix JVLLC. IBH and Duke University have patent rights and have licensed technologies to BioMimetix JVLLC. The authors report no other conflicts of interest in this work.

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