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Front Cell Infect Microbiol. 2017 Mar 14;7:81. doi: 10.3389/fcimb.2017.00081. eCollection 2017.

P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions.

Author information

1
Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
2
Molecular Pathology Division, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
3
Department of Biomedicine, Aarhus University Aarhus, Denmark.

Abstract

This review discusses the biology and behavior of Propionibacterium acnes (P. acnes), a dominant bacterium species of the skin biogeography thought to be associated with transmission, recurrence and severity of disease. More specifically, we discuss the ability of P. acnes to invade and persist in epithelial cells and circulating macrophages to subsequently induce bouts of sarcoidosis, low-grade inflammation and metastatic cell growth in the prostate gland. Finally, we discuss the possibility of P. acnes infiltrating the brain parenchyma to indirectly contribute to pathogenic processes in neurodegenerative disorders such as those observed in Parkinson's disease (PD).

KEYWORDS:

BPH; Parkinson disease; Propionibacterium acnes; prostate cancer; sarcoidosis

PMID:
28352613
PMCID:
PMC5348501
DOI:
10.3389/fcimb.2017.00081
[Indexed for MEDLINE]
Free PMC Article

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