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Cardiol Res. 2010 Dec;1(1):1-7. doi: 10.4021/cr101e. Epub 2010 Nov 20.

ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population.

Author information

1
Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India; Departments of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
2
Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India.
3
Departments of Cardiology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
4
Department of Clinical Biochemistry, Kashmri University, Hazratbal, Srinagar, Kashmir, India.
5
Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India; Department of Clinical Biochemistry, Kashmri University, Hazratbal, Srinagar, Kashmir, India.

Abstract

BACKGROUND:

The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population.

MATERIALS AND METHODS:

We designed a case control study, where 52 hypertensive cases were studied for ACE I/D polymorphism against 150 age/sex matched controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of ACE I/D genotype. Fisher's Chi square test was used for calculation of P value and OR.

RESULTS:

We found the frequency of ACE DD genotype to be 46.15% (24/52), II 23.07% (12/52) and DI 30.77% (16/52) in 52 hypertensive cases.

CONCLUSIONS:

The ACE I/D genotype is positively associated with hypertension in our population.

KEYWORDS:

ACE; Hypertension; Kashmir; Polymorphism; RFLP

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