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Fitoterapia. 2017 Jun;119:40-44. doi: 10.1016/j.fitote.2017.03.012. Epub 2017 Mar 27.

Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don.

Author information

1
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China.
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China.
3
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China. Electronic address: ljxuan@simm.ac.cn.

Abstract

Phytochemical investigation of the 70% acetone extract of the whole plant of Scutellaria barbata D. Don afforded six new neo-clerodane diterpenoids, scubatines A-F (1-6), and four known analogues (7-10). Their structures were elucidated on the basis of extensive spectroscopic analyses. Cytotoxic activity against the HL-60 and A549 cell lines was assessed for all isolated compounds. Compound 9 exhibited moderate activity against HL-60 with an IC50 value of 5.6μM. Compound 6 showed weak cytotoxic activity against A549 and HL-60 with IC50 values of 10.4 and 15.3μM, respectively.

KEYWORDS:

Cytotoxic activity; Lamiaceae; Scutellaria barbata D. Don; neo-Clerodane diterpenoids

PMID:
28351723
DOI:
10.1016/j.fitote.2017.03.012
[Indexed for MEDLINE]

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