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Br J Cancer. 2017 Apr 25;116(9):1229-1233. doi: 10.1038/bjc.2017.81. Epub 2017 Mar 28.

Dependence of cancer risk from environmental exposures on underlying genetic susceptibility: an illustration with polycyclic aromatic hydrocarbons and breast cancer.

Author information

1
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA.
2
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA.
3
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, VIC 3010, Australia.
4
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St Nicholas Avenue, New York, NY 10032, USA.

Abstract

BACKGROUND:

Most studies of environmental risk factors and breast cancer are conducted using average risk cohorts.

METHODS:

We examined the association between polycyclic aromatic hydrocarbon (PAH)-albumin adducts in bloods from baseline and breast cancer risk in a prospective nested case-control study (New York site of the BCFR, 80 cases and 156 controls). We estimated the 10-year absolute breast cancer risk by a risk model that uses pedigree information (BOADICEA) and evaluated whether the increased risk from PAH differed by absolute risk.

RESULTS:

Women with detectable levels of PAH had a twofold association with breast cancer risk (odds ratio (OR)=2.04; 95% CI=1.06-3.93) relative to women with non-detectable levels. The association increased with higher levels of PAH (⩾median) and by a higher level of absolute breast cancer risk (10-year risk ⩾3.4%: OR=4.09, 95% CI=1.38-12.13).

CONCLUSIONS:

These results support that family-based cohorts can be an efficient way to examine gene-environment interactions.

PMID:
28350789
PMCID:
PMC5418454
DOI:
10.1038/bjc.2017.81
[Indexed for MEDLINE]
Free PMC Article

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