Send to

Choose Destination
J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):328-337. doi: 10.1097/QAI.0000000000001381.

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals.

Author information

*The Kirby Institute, UNSW Medicine, UNSW Australia, New South Wales, Australia; †St Vincent's Hospital, Sydney, Darlinghurst, New South Wales, Australia; ‡The Peter Doherty Institute for Infection and Immunity, Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia; §The Alfred Hospital, Melbourne, Victoria, Australia; ‖Monash University, Victoria, Australia; ¶Blood Systems Research Institute, San Francisco, CA; #University of California, San Francisco, CA; **Veterans Affairs Medical Centre, San Francisco, CA; ††The Westmead Institute for Medical Research, Westmead, New South Wales, Australia; ‡‡University of Sydney, Sydney, New South Wales, Australia; §§Prince of Wales Hospital, Randwick, New South Wales, Australia; ‖‖The Albion Centre, Surry Hills, New South Wales, Australia; ¶¶Prince of Wales Clinical School, UNSW Medicine, UNSW Australia, New South Wales, Australia; ##School of Public Health, UNSW Medicine, UNSW Australia, New South Wales, Australia; and ***The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.



Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted.


We studied 3 patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV-specific CD4 T-cell responses, HIV RNA, and DNA in plasma, peripheral blood mononuclear cells, isolated CD4 T cells from peripheral blood, and lymph node cells. The patients remained on antiretroviral therapy throughout the follow-up period.


All patients have been in continued remission for 4-6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir-related measurements in all 3 patients, changes in immune response varied with pronounced reductions in 2 patients and a less dramatic reduction in 1 patient. One patient experienced unexpected viral rebound 4 years after HSCT.


These 3 cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in 1 patient indicates that replication competent HIV can re-emerge several years after HSCT despite these marked changes.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wolters Kluwer Icon for PubMed Central
Loading ...
Support Center