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JMM Case Rep. 2016 Oct 31;3(5):e005069. doi: 10.1099/jmmcr.0.005069. eCollection 2016 Oct.

Successful treatment of recurrent Helicobacter fennelliae bacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy.

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Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
Department of Microbiology, School of Pharmacy, Aichi Gakuin University , Aichi , Japan.
Department of Clinical Laboratory, National Center for Global Health and Medicine , Tokyo , Japan.
Respiratory Medicine, National Center for Global Health and Medicine , Tokyo , Japan.



Helicobacter fennelliae is an enterohepatic Helicobacter species causing bacteraemia in immunocompromised hosts. Only a few cases of recurrent H. fennelliae bacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment for H. fennelliae infection.


H. fennelliae bacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy for Helicobactercinaedi bacteraemia. Bacteraemia recurred despite the long-term antibiotic therapy. We hypothesized that the H. fennelliae bacteraemia originated from endogenous infection in the intestinal tract due to the long-term damage of the enteric mucosa by platinum-based drugs and performed selective digestive decontamination (SDD) with kanamycin. Bacteraemia did not recur after SDD.


Our observations indicate that clinicians should be aware of possible recurrent H. fennelliae bacteraemia, which could be effectively prevented by SDD with kanamycin.


Helicobacter fennelliae; recurrent bacteremia, lung cancer, chemotherapy; selective digestive decontamination, kanamycin

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