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Int J Infect Dis. 2017 Jun;59:22-24. doi: 10.1016/j.ijid.2017.03.018. Epub 2017 Mar 24.

First report of human parechovirus type 3 infection in a pregnant woman.

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Department of Neurology, Matsushita Memorial Hospital, Osaka, Japan. Electronic address:
Department of General Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
Department of Obstetrics and Gynecology, Matsushita Memorial Hospital, Osaka, Japan.
Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, Japan.
Department of Neurology, Matsushita Memorial Hospital, Osaka, Japan.


Human parechovirus type 3 (HPeV3) can cause serious conditions in neonates, such as sepsis and encephalitis, but data for adults are lacking. The case of a pregnant woman with HPeV3 infection is reported herein. A 28-year-old woman at 36 weeks of pregnancy was admitted because of myalgia and muscle weakness. Her grip strength was 6.0kg for her right hand and 2.5kg for her left hand. The patient's symptoms, probably due to fasciitis and not myositis, improved gradually with conservative treatment, however labor pains with genital bleeding developed unexpectedly 3 days after admission. An obstetric consultation was obtained and a cesarean section was performed, with no complications. A real-time PCR assay for the detection of viral genomic ribonucleic acid against HPeV showed positive results for pharyngeal swabs, feces, and blood, and negative results for the placenta, umbilical cord, umbilical cord blood, amniotic fluid, and breast milk. The HPeV3 was genotyped by sequencing of the VP1 region. The woman made a full recovery and was discharged with her infant in a stable condition.


Adult; Muscle weakness; Myalgia; Parechovirus type 3; Pregnancy

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